Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.

A number of regulators of SUMOylation have been beforehand linked to senescence however most targets of this modification in senescent cells stay unidentified. Utilizing a

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Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane.

VAPB (vesicle-associated membrane protein-associated protein B) is a tail-anchored protein that’s current at a number of contact websites of the endoplasmic reticulum (ER). We now

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(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A

DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate quite a few frameshift mutations at repetitive sequences acknowledged as microsatellite instability (MSI). When coding mononucleotide repeats (cMNRs)

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Uncover the Nuclear Proteomic Landscape with Enriched Nuclei Followed by Label-Free Quantitative Mass Spectrometry

Handled with gentle pulse or beneath sure diurnal situations, photoreceptors can translocate into nucleus adopted by conformation change. Many vital elements of sunshine signaling pathways

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